Tolerogenic dendritic cells and their potential applications

Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications.

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such as lipopolysaccharides (LPS) and nucleic acids via their pattern recognition receptors, which trigger signaling of their maturation and effector functions. Furth...

Genetic Engineering of Dendritic Cells to Enhance Their Tolerogenic Potential

spleen and liver dendritic cells differ in their tolerogenic and cytokine induction potential

dendritic cells (dcs) play an important role in induction of cellular immune responses. it seems that dcs that reside in different organs may be distinct in their ability to  induce immune responses. this study was done to address the differences between spleen and liver dcs in induction of immune response and/or tolerance. cd11c+  dcs were separated from the liver and spleen of c57bl/6 mice an...

CD40 Knocked Down Tolerogenic Dendritic Cells Decrease Diabetic Injury

Background: Type-1 diabetes (T1D) is an autoimmune disease in which T lymphocytes destroy insulin-producing β-cells. Control of self-reactive T lymphocytes and recovery of diabetic injury is the end point of T1D. Objective: To investigate generation of tolerogenic dendritic cells (tolDCs) as an innovative method of diabetes therapy. Methods: Lentivirus vector production was achieved by GIPZ mou...

Tolerogenic dendritic cells.

Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by recep...